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Book Neuroendocrinology of Mood (Current Topics in Neuroendocrinology)

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Neuroendocrinology of Mood (Current Topics in Neuroendocrinology)

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    Available in PDF - DJVU Format | Neuroendocrinology of Mood (Current Topics in Neuroendocrinology).pdf | Language: ENGLISH
    Detlev Ganten(Editor)

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The tridecapeptide neurotensin (NT) was first identified in bovine hypothalamic extracts and characterized by Carraway and Leeman (1973,1975,1976) and has subsequently been found in all classes of vertebrates(Carraway and Leeman 1976; Kitabgi et al. 1976; Kataoka et al. 1979; Langer et al. 1979; Reinecke et al. 1980a; Cooper et al. 1981; Grant et al. 1982; Carraway et al. 1982; Eldred and Karten 1983), many invertebrates (Reineckeet al. 1980 b; Grimmelikhuijzen et al. 1981; Price et al. 1982), and certain bacteria (Bhatnagar and Carraway 1981). It is distributed throughout the mammalian central nervous system (CNS) (Uhl and Snyder 1977 a, b),gastrointestinal tract (Sundler et al. 1977; Schultzberg et al. 1980), cerebrospinal fluid (CSF), adrenals, pancreas, and plasma (Fernstrom et al. 1980). When administered systemically, the peptide has a variety of effectssuch as hypotension, hyperglycemia, decreased gastric acid secretion, decreased gut motility, and altered secretion of anterior pituitary hormones (Leeman and Carraway 1982). NT apparently does not cross the blood-brainbarrier in appre­ ciable quantities; however, when administered directly into the CNS, it produces a number of physiological and behavioral effects. A burgeoning body of evidence supports the role of NT as a neurotransmitteror neuromodulator. Thus far, het­ erogeneous CNS distribution, release of NT upon neuronal depolarization, satu­ rable and specific binding of NT to receptors, and degradation by peptidases have all been demonstrated.
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Book details

  • PDF | 344 pages
  • Detlev Ganten(Editor)
  • Springer-Verlag; Softcover reprint of the original 1st ed. 1988 edition (1 Jan. 1988)
  • English
  • 8
  • Health, Family & Lifestyle

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